Description

4-Benzyloxy-1-Ethynyl-3-Methoxy-Benzene is a specialized aromatic compound featuring a benzyloxy-protected phenol, an ethynyl group, and a methoxy substituent, making it a versatile building block in advanced organic synthesis. Its unique structure provides a valuable handle for further functionalization via Sonogashira coupling or click chemistry, enabling the construction of complex molecular architectures. This intermediate is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly those requiring arylacetylene or diaryl ether scaffolds.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a monomer or precursor for conjugated polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile building block for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki).
• Academic & R&D: Employed in methodological studies and the discovery of new catalytic systems or reaction pathways.
• Fine Chemical Production: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	4-Benzyloxy-1-Ethynyl-3-Methoxy-Benzene
CAS No.	144735-54-6
Molecular Formula	C₁₆H₁₄O₂
Molecular Weight	238.28 g/mol
Synonyms	1-Ethynyl-4-(benzyloxy)-3-methoxybenzene; 3-Methoxy-4-(phenylmethoxy)phenylacetylene; 4-(Benzyloxy)-3-methoxyphenylacetylene; 4-(Phenylmethoxy)-3-methoxyphenylacetylene; 1-Ethynyl-3-methoxy-4-(phenylmethoxy)benzene; Benzene, 4-(benzyloxy)-1-ethynyl-3-methoxy-; 144735-54-6
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-1-Ethynyl-3-Methoxy-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.