Description

Fmoc-Dl-Norvaline CAS NO 144701-21-3 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in the Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which provides orthogonal protection that can be cleanly removed under mild basic conditions, enabling the efficient and sequential construction of complex peptides. This compound is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, sequential assembly of custom peptide sequences using Fmoc chemistry.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) for peptide drugs targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Probe Development: Serves as a modified amino acid for introducing the norvaline side chain into peptides used for labeling, imaging, or creating affinity probes.
• Structure-Activity Relationship (SAR) Studies: The DL-mixture (racemate) is valuable for comparative studies to understand the stereochemical requirements for biological activity in peptide leads.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Academic and Industrial Research: A standard reagent in biochemistry and organic chemistry laboratories for investigating peptide structure, function, and synthesis methodologies.

Basic Information

Item	Details
Product Name	Fmoc-Dl-Norvaline
CAS No.	144701-21-3
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-norvaline; Fmoc-DL-Nva-OH; Fmoc-DL-2-Aminopentanoic Acid; (RS)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pentanoic Acid; DL-2-(Fmoc-amino)valeric Acid; N-α-Fmoc-DL-norvaline; Fmoc-DL-α-aminovaleric acid; N-(9-Fluorenylmethoxycarbonyl)-DL-norvaline
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Norvaline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm the racemic composition, ensuring it meets the stringent requirements for peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Composition (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.