Description

(R)-1-Boc-2-Cyanopyrrolidine is a high-purity, chiral building block essential for modern pharmaceutical synthesis. This compound is a key intermediate in the development of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological disorders. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of dipeptidyl peptidase-4 (DPP-4) inhibitors and other enzyme-targeting therapeutics.
• Peptidomimetic Chemistry: Used to introduce the (R)-2-cyanopyrrolidine scaffold, a common motif in protease inhibitor design.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create complex chiral centers.
• API Development: Employed in the research, development, and scale-up manufacturing of novel drug candidates.
• Chemical Biology: Used in the design and synthesis of activity-based probes for studying enzyme function.
• Custom Synthesis: A foundational block for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	(R)-1-Boc-2-Cyanopyrrolidine
CAS No.	144688-70-0
Molecular Formula	C10H16N2O2
Molecular Weight	196.25 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-cyanopyrrolidine; (R)-2-Cyano-1-Boc-pyrrolidine; (R)-N-Boc-2-cyanopyrrolidine; (R)-1-Boc-2-cyano-pyrrolidine; tert-Butyl (R)-2-cyanopyrrolidine-1-carboxylate; (R)-1-Boc-pyrrolidine-2-carbonitrile; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-Cyanopyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and IR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, chiral excess, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.