Description

Cyclopropaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is a high-purity, chiral organic intermediate of significant interest in advanced chemical synthesis. This compound matters for its role as a sophisticated building block in the development of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific (1R-Cis) configuration is critical for bioactivity.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development and testing of new chiral catalysts and synthetic methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance ingredients, flavors, and other specialty chemicals requiring high stereochemical purity.
• Academic & Industrial R&D: A critical material for process chemistry optimization, route scouting, and scale-up studies in both academic and corporate laboratory settings.

Basic Information

Product Name	Cyclopropaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci)
CAS No.	144686-75-9
Molecular Formula	C9H13NO
Molecular Weight	151.21 g/mol
Synonyms	(1R,3S)-3-Acetyl-2,2-dimethylcyclopropaneacetonitrile; (1R-cis)-3-Acetyl-2,2-dimethylcyclopropaneacetonitrile; 2,2-Dimethyl-3-oxocyclopropaneacetonitrile, (1R,3S)-; 144686-75-9; (1R,3S)-rel-3-Acetyl-2,2-dimethylcyclopropaneacetonitrile
EINECS	Contact for details

Quality Control

Our Cyclopropaneacetonitrile, 3-Acetyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.