Description

(S)-2-Chloro-Mandelamide is a high-purity chiral intermediate of significant importance in modern synthetic chemistry. Its value lies in its role as a key building block for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides, where specific stereochemistry is essential for biological activity and environmental safety.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in academic and industrial research focused on developing new asymmetric synthetic methodologies.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require high stereochemical purity.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in chiral separation techniques like HPLC.

Basic Information

Product Name	(S)-2-Chloro-Mandelamide
CAS No.	144664-09-5
Molecular Formula	C8H8ClNO2
Molecular Weight	185.61 g/mol
Synonyms	(S)-2-Chloro-2-phenylglycolamide; (S)-α-Chloromandelamide; (S)-2-Chloro-2-hydroxy-2-phenylacetamide; (2S)-2-Chloro-2-hydroxy-2-phenylethanamide; (S)-2-Chloro-2-phenyl-2-hydroxyacetamide; (S)-Mandelamide, 2-chloro-; (S)-(-)-2-Chloromandelamide
EINECS	Contact for details

Quality Control

Our (S)-2-Chloro-Mandelamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.