Description

Flg-2 Protein CAS NO 144590-76-1 is a highly purified recombinant protein derived from flagellin, a key structural component of bacterial flagella. This product is essential for immunological research and therapeutic development due to its potent agonist activity on the Toll-like receptor 5 (TLR5) pathway. It is primarily utilized by biotechnology and pharmaceutical companies, as well as academic research institutions, for applications in vaccine adjuvants, immunomodulation studies, and innate immune response research.

Application

• Vaccine Adjuvant Development: Used as a potent immunostimulant to enhance the efficacy of prophylactic and therapeutic vaccines.
• Immunology Research: A critical tool for studying TLR5-mediated signaling pathways and innate immune system activation.
• Therapeutic Protein Engineering: Serves as a fusion partner or carrier to improve the immunogenicity of target antigens.
• Cell Culture & Stimulation: Employed to activate immune cells like dendritic cells and macrophages in vitro for functional assays.
• Drug Delivery Systems: Investigated for use in nanoparticle formulations to target specific immune responses.
• Diagnostic Reagent Production: Used in the development of immunoassays and detection kits for inflammatory markers.

Basic Information

Product Name	Flg-2 Protein
CAS No.	144590-76-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Recombinant Flagellin Fragment; TLR5 Agonist; Bacterial Flagellin Protein; FliC Protein; Salmonella typhimurium Flagellin; Innate Immune Stimulator; Adjuvant Protein; CAS 144590-76-1
EINECS	Contact for details

Quality Control

Our Flg-2 Protein is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC, endotoxin level determination, and biological activity verification via cell-based assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, potency, and specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted protein solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (HPLC)	≥ 98.0%
Endotoxin Level	< 1.0 EU/μg
Biological Activity (Cell-based Assay)	Meets reference standard
Identification (IR)	Conforms to structure
Solubility	Soluble in aqueous buffers
Protein Content (UV)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.