Description

Benzenepropanoic Acid, α-Fluoro-α-Methyl-β-Oxo-, Methyl Ester, (R)- (9Ci) is a high-value, chiral fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, incorporating both fluorine and a β-keto ester moiety, which makes it a versatile precursor for constructing complex, biologically active molecules. This compound is primarily needed by research and development chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and inflammation.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom and chiral center can enhance biological activity and environmental stability.
• Fluorine Chemistry Research: Serves as a model compound for studying the effects of fluorine substitution and chiral induction in β-keto ester systems within academic and industrial R&D settings.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.

Basic Information

Product Name	Benzenepropanoic Acid, α-Fluoro-α-Methyl-β-Oxo-, Methyl Ester, (R)- (9Ci)
CAS No.	144462-33-9
Molecular Formula	C11H11FO3
Molecular Weight	210.20 g/mol
Synonyms	(R)-Methyl 2-Fluoro-2-methyl-3-oxo-3-phenylpropanoate; Methyl (R)-2-Fluoro-2-methyl-3-oxo-3-phenylpropionate; (R)-α-Fluoro-α-methyl-β-oxo-benzenepropanoic Acid Methyl Ester; (R)-Methyl α-Fluoro-α-methyl-β-oxo-hydrocinnamate; 144462-33-9; (R)-Enantiomer of Methyl 2-Fluoro-2-methyl-3-oxo-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.