Description

Amyloid β-Protein (1-40) (Mouse, Rat) CAS NO 144409-98-3 is a synthetic peptide fragment corresponding to the N-terminal 1-40 amino acid sequence of the murine amyloid-beta protein, a key component in the study of Alzheimer's disease pathology. This high-purity peptide is essential for researchers developing and validating in vitro and in vivo models of amyloidogenesis and neurotoxicity. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies focused on neurodegenerative disease research and therapeutic discovery.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta aggregation kinetics, fibril formation, and structure-activity relationships.
• Drug Discovery & Screening: A critical substrate for high-throughput screening (HTS) assays to identify potential inhibitors of Aβ aggregation or toxicity.
• Animal Model Development: Used to induce amyloid plaque formation and cognitive deficits in rodent models (mice, rats) for preclinical Alzheimer's disease studies.
• Biomarker & Diagnostic Tool Development: Serves as a standard or antigen in immunoassays (ELISA, Western Blot) for detecting Aβ species.
• Mechanistic Toxicology: Investigating the cellular and molecular mechanisms of Aβ-induced neuronal cell death and synaptic dysfunction.
• Antibody & Therapeutic Validation: Essential for testing the binding efficacy and functional activity of therapeutic antibodies or other biologics targeting Aβ.

Basic Information

Item	Details
Product Name	Amyloid β-Protein (1-40) (Mouse, Rat)
CAS No.	144409-98-3
Molecular Formula	C194H295N55O58S
Molecular Weight	4330.8 g/mol
Synonyms	Aβ (1-40) (Mouse/Rat); Amyloid β-Protein (1-40) murine; Aβ1-40 (rodent); Amyloid β-Peptide (1-40) (Mouse); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; β-Amyloid (1-40), Mouse; rAβ1-40; CAS 144409-98-3
EINECS	Contact for details

Quality Control

Every batch of our Amyloid β-Protein (1-40) (Mouse, Rat) is manufactured and analyzed under strict quality management systems. The peptide identity and purity are rigorously verified using advanced analytical techniques including HPLC and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical data to ensure reproducibility and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Molecular Weight	4330.8 ± 2 Da (by mass spectrometry)
Solubility	Soluble in water, DMSO, or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.