Description

N,N'-Bis[(tert-Butyloxy)Carbonyl]-L-Homocystine Dimethyl Ester is a high-purity, Boc-protected derivative of the amino acid homocystine, designed for advanced synthetic applications. This compound is a critical building block in the synthesis of complex peptides and modified biomolecules, offering superior control over reaction pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of peptides containing homocystine or modified cysteine residues.
• Medicinal Chemistry Research: Used in the design and development of enzyme inhibitors, receptor ligands, and other bioactive compounds.
• Bioconjugation Chemistry: Serves as a protected linker or spacer molecule for creating stable, defined protein-drug conjugates or diagnostic probes.
• Proteomics & Biochemistry: Employed in the study of disulfide bond formation, protein folding, and the synthesis of non-natural amino acid analogs for structural studies.
• Chemical Biology Tool: Facilitates the site-specific introduction of functional groups or labels into peptides under controlled conditions.

Basic Information

Product Name	N,N'-Bis[(tert-Butyloxy)Carbonyl]-L-Homocystine Dimethyl Ester
CAS No.	144373-70-6
Molecular Formula	C₂₂H₄₀N₂O₈S₂
Molecular Weight	524.68 g/mol
Synonyms	Boc-Homocystine(OMe)-OH; Di-Boc-L-Homocystine Dimethyl Ester; L-Homocystine, N,N'-bis[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester; (2R,2'R)-Dimethyl 2,2'-(disulfanediylbis(2-(tert-butoxycarbonylamino)butanoate)); Boc-Hcy(OMe)-OH; N,N'-Di-Boc-L-homocystine dimethyl ester; (R,R)-Di-Boc-homocystine dimethyl ester
EINECS	Contact for details

Quality Control

Our N,N'-Bis[(tert-Butyloxy)Carbonyl]-L-Homocystine Dimethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.