Description

H-Gln(Mtt)-Oh is a protected glutamine derivative, specifically an N-terminal glutamine with an Mtt (4-methyltrityl) protecting group on the side chain amide nitrogen. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of glutamine residues without side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research reagents. The product is supplied as a high-purity intermediate to ensure optimal coupling efficiency and final peptide integrity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, specifically for introducing glutamine residues.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide drugs, including hormones, antimicrobial peptides, and targeted therapies.
• Bioconjugation: Serves as a precursor for creating functionalized peptides for coupling to carriers, labels, or surfaces.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR).
• Academic & Industrial Research: Fundamental reagent for studying peptide structure, function, and synthesis methodology.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	H-Gln(Mtt)-Oh
CAS No.	144317-21-5
Molecular Formula	C26H28N2O3
Molecular Weight	416.52 g/mol
Synonyms	Fmoc-Gln(Mtt)-OH; N-α-Fmoc-N-γ-(4-methyltrityl)-L-glutamine; L-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-(4-methylphenyl)diphenylmethyl]-; N-α-Fmoc-N-γ-Mtt-L-glutamine; Fmoc-Gln(Mtt)-OH; Fmoc-L-glutamine(Mtt)-OH; Fmoc-Gln(Mtt); Protected Glutamine derivative
EINECS	Contact for details

Quality Control

Our H-Gln(Mtt)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.