Description

(E)-Methyl 5-(4-Fluorophenyl)-3-Oxopent-4-Enoate is a high-purity, non-racemic chiral building block and synthetic intermediate of significant commercial importance. Its defined stereochemistry and functional groups make it a critical precursor for the synthesis of complex, biologically active molecules. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated drug candidates, including potential kinase inhibitors and anti-inflammatory agents.
• Chiral Synthesis: Serves as a versatile, enantiomerically pure starting material for asymmetric synthesis in medicinal chemistry.
• Agrochemical Research: Used in the development of advanced fluorinated pesticides and herbicides, leveraging the fluorine atom's metabolic stability.
• Material Science Precursor: Potential intermediate for synthesizing specialty polymers and liquid crystals with specific optical properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory research in organic synthesis.

Basic Information

Product Name	(E)-Methyl 5-(4-Fluorophenyl)-3-Oxopent-4-Enoate
CAS No.	144224-15-7
Molecular Formula	C12H11FO3
Molecular Weight	222.21 g/mol
Synonyms	Methyl (E)-5-(4-Fluorophenyl)-3-oxopent-4-enoate; (E)-Methyl 5-(p-Fluorophenyl)-3-oxo-4-pentenoate; 4-Pentenoic acid, 5-(4-fluorophenyl)-3-oxo-, methyl ester, (E)-; Methyl 5-(4-fluorophenyl)-3-oxo-4-pentenoate; (E)-5-(4-Fluorophenyl)-3-oxopent-4-enoic acid methyl ester; 144224-15-7; MFCD30132612
EINECS	Contact for details

Quality Control

Our (E)-Methyl 5-(4-Fluorophenyl)-3-Oxopent-4-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and isomeric purity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with every shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isomeric Purity (HPLC)	≥ 99.0% (E-isomer)
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.