Description

2-(2-((9H-Fluoren-9-Yl)Oxy)Acetamido)-5,5,5-Trifluoropentanoic Acid is a specialized fluorinated amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound matters as a high-purity building block for the synthesis of complex peptides and bioactive molecules, where the Fmoc group enables selective deprotection under mild conditions. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in solid-phase peptide synthesis (SPPS) and the development of novel therapeutics, including those targeting metabolic and neurological disorders.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key fluorinated amino acid building block for the controlled assembly of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those incorporating trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Proteomics Research: Employed in the synthesis of peptide standards, probes, and substrates for enzyme activity studies and biomarker discovery.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules due to its reactive carboxylic acid functionality.
• Material Science: Can be incorporated into specialty polymers and advanced materials to impart unique fluorinated properties.
• Academic & Contract Research: A critical reagent for synthetic chemistry and medicinal chemistry projects in university and CRO laboratories.

Basic Information

Product Name	2-(2-((9H-Fluoren-9-Yl)Oxy)Acetamido)-5,5,5-Trifluoropentanoic Acid
CAS No.	144207-41-0
Molecular Formula	C21H18F3NO4
Molecular Weight	405.37 g/mol
Synonyms	Fmoc-5,5,5-trifluoronorleucine; Fmoc-Tfn-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5,5,5-trifluoronorleucine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5,5,5-trifluoropentanoic acid; 5,5,5-Trifluoro-L-norleucine N-Fmoc derivative; Fmoc-5,5,5-trifluoro-L-norleucine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5,5,5-trifluoropentanoic acid; N-α-Fmoc-5,5,5-trifluoronorleucine
EINECS	Contact for details

Quality Control

Our 2-(2-((9H-Fluoren-9-Yl)Oxy)Acetamido)-5,5,5-Trifluoropentanoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (where applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.