Description

Cefamandole CAS NO 144125-09-7 is a second-generation cephalosporin antibiotic belonging to the β-lactam class. It is valued for its broad-spectrum activity against a range of Gram-positive and Gram-negative bacteria, including some penicillinase-producing strains. This makes it a critical intermediate and active pharmaceutical ingredient (API) for manufacturers in the pharmaceutical industry, particularly for producing sterile injectable formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in the synthesis of cefamandole sodium for injection, a parenteral antibiotic.
• Antibacterial Formulations: Used in the development of broad-spectrum antibiotic drugs targeting respiratory, skin, and soft tissue infections.
• Research & Development: Serves as a key reference standard and intermediate in microbiological and pharmacological research studies.
• Veterinary Medicine: Potential application in developing antibacterial treatments for veterinary use.
• Hospital & Clinical Use: Essential for compounding pharmacies and hospital settings requiring specific antibiotic preparations.

Basic Information

Product Name	Cefamandole
CAS No.	144125-09-7
Molecular Formula	C18H18N6O5S2
Molecular Weight	462.50 g/mol
Synonyms	Cefamandole; Cefamandolum; Cefamandole Base; (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Mandol (as the sodium salt); Cefamandole Nafate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Cefamandole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing results for identity, purity, and impurities as per in-house specifications aligned with common pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH limits
Specific Optical Rotation	Contact for details
Bacterial Endotoxins	< 0.10 EU/mg (for injectable grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.