Description

Shaker B Inactivating Peptide is a specific, cell-permeable peptide inhibitor designed to target and inactivate the Shaker B potassium channel. This compound is a critical research tool for studying ion channel function, neuronal excitability, and signal transduction pathways in cellular and molecular biology. It is primarily utilized by researchers and scientists in the fields of neuroscience, pharmacology, and cardiovascular research to dissect the physiological roles of potassium channels and explore potential therapeutic targets.

Application

• Neuroscience Research: Investigation of potassium channel function in neuronal signaling, action potential generation, and synaptic transmission.
• Cardiovascular Studies: Research into the role of Shaker-type potassium channels in cardiac electrophysiology and arrhythmia mechanisms.
• Pharmacological Screening: Used as a reference inhibitor in high-throughput assays to discover and characterize novel ion channel modulators.
• Cellular Physiology: Study of cellular excitability and membrane potential regulation in various cell types, including muscle and endocrine cells.
• Signal Transduction Pathways: Elucidation of downstream effects following specific potassium channel blockade.
• Academic & Institutional Research: Fundamental research tool in university and institutional laboratories for graduate and post-doctoral studies.

Basic Information

Product Name	Shaker B Inactivating Peptide
CAS No.	144119-58-4
Molecular Formula	C44H71N13O12S
Molecular Weight	982.2 g/mol
Synonyms	Shaker B Inactivation Peptide; Shaker B Ball Peptide; Inactivating Ball Peptide; Shaker B Channel Inactivation Domain; IBP; Kv1 Inactivating Peptide; Voltage-Gated Potassium Channel Inactivation Peptide; Ac-RVRLSFFKGLKNVIREA-NH2 (Acetylated N-terminus, Amide C-terminus)
EINECS	Contact for details

Quality Control

Our Shaker B Inactivating Peptide is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and peptide content are available upon request, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.