Description

Desmethyl Rizatriptan is a key pharmaceutical intermediate and metabolite of the anti-migraine drug Rizatriptan. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories involved in the development and quality control of neurological and cardiovascular medications.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of Rizatriptan and related tryptamine-based therapeutics.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the pharmacokinetics and metabolic pathways of Rizatriptan.
• Drug Impurity Profiling: Essential for identifying and quantifying related substances in Active Pharmaceutical Ingredient (API) batches to ensure purity and safety.
• Pharmacological Research: Serves as a tool compound in preclinical research to investigate the structure-activity relationships (SAR) of serotonin (5-HT1B/1D) receptor agonists.
• Quality Control & Assurance: Employed in analytical laboratories for method development and validation in HPLC, LC-MS, and other chromatographic systems.
• Regulatory Compliance Testing: Used to support regulatory filings (e.g., with FDA, EMA) by providing definitive characterization of drug metabolites.

Basic Information

Product Name	Desmethyl Rizatriptan
CAS No.	144034-84-4
Molecular Formula	C14H17N5
Molecular Weight	255.32 g/mol
Synonyms	N-Methyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; 3-[2-(Methylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole; Desmethyl Rizatriptan; Rizatriptan Impurity; Rizatriptan Metabolite; Rizatriptan Related Compound; MK-0462 N-Desmethyl; L-741,604
EINECS	Contact for details

Quality Control

Our Desmethyl Rizatriptan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The material should be kept under inert conditions if long-term stability is required. Avoid exposure to moisture and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.