Description

Perlecan is a high-purity proteoglycan, a key structural and functional component of the extracellular matrix. This product, identified as CAS NO 143972-95-6, is critical for research and development in advanced biomaterial and life science applications due to its role in cell signaling, adhesion, and tissue organization. It is primarily utilized by biotechnology firms, academic research institutions, and pharmaceutical developers focused on regenerative medicine, cancer research, and advanced drug delivery systems.

Application

• Biomedical Research: Used as a critical substrate for studying cell-matrix interactions, angiogenesis, and tumor biology in vitro.
• Tissue Engineering: Incorporated into scaffolds and hydrogels to enhance biocompatibility and mimic native tissue architecture for regenerative medicine.
• Drug Delivery Systems: Explored as a component in targeted delivery platforms due to its binding affinity for various growth factors and ligands.
• Diagnostic Development: Serves as a reference standard or coating agent in assay development for biomarkers related to basement membrane disorders.
• Cell Culture Enhancement: Used to coat culture surfaces to improve the attachment and differentiation of specific cell types, including stem cells.

Basic Information

Product Name	Perlecan
CAS No.	143972-95-6
Molecular Formula	Contact for details
Molecular Weight	~400-470 kDa (Core Protein)
Synonyms	HSPG2; Heparan Sulfate Proteoglycan 2; Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein; PLC; Endorepellin; SJS; SJS1; PRCAN
EINECS	Contact for details

Quality Control

Our Perlecan is produced and handled under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional assays. We adhere to relevant guidelines for research-grade biochemicals to support reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE/Western Blot)	Conforms
Purity (SDS-PAGE)	> 90%
Protein Content (BCA)	> 95%
Endotoxin Level (LAL)	< 1.0 EU/mg
Biological Activity (Cell Adhesion Assay)	Conforms
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.