Description

Axl Protein CAS NO 143891-42-3 is a high-purity recombinant protein that functions as a receptor tyrosine kinase, playing a critical role in cellular signaling pathways. This protein is essential for research and development in targeted therapeutics, particularly in oncology and immunology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies for applications in drug discovery, biochemical assays, and cell-based studies.

Application

• Drug Discovery & Screening: Used as a target protein in high-throughput screening (HTS) assays to identify and validate novel small molecule inhibitors or therapeutic antibodies.
• Biochemical Research: Essential for in vitro kinase activity assays, phosphorylation studies, and understanding downstream signaling cascades involving the Axl receptor.
• Cell-Based Assays: Employed in cellular models to study Axl-mediated processes such as cell proliferation, migration, and survival in cancer research.
• Antibody Development & Validation: Serves as a critical antigen for the production, purification, and characterization of monoclonal and polyclonal antibodies.
• Diagnostic Development: Used as a standard or coating antigen in the development of immunoassays and diagnostic kits for detecting Axl expression or related biomarkers.
• Structural Biology: Provides material for X-ray crystallography, NMR, and other structural studies to elucidate drug-protein interactions and guide rational drug design.

Basic Information

Product Name	Axl Protein
CAS No.	143891-42-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL receptor tyrosine kinase; UFO; JTK11; Recombinant Human AXL; AXL Protein Kinase; AXL Tyrosine Kinase; AXL Cytoplasmic Domain
EINECS	Contact for details

Quality Control

Our Axl Protein is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, endotoxin level determination, and functional activity validation in kinase or binding assays. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Mass Spec)	Conforms
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by functional assay
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.