Description

3,4-Difluorophenylacetylene is a high-purity fluorinated aromatic alkyne building block essential for advanced organic synthesis. This compound is valued for its role in introducing the difluorophenylacetylene moiety, enabling the construction of complex molecules with tailored electronic and steric properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances bioavailability and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Click Chemistry: An ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating the rapid and modular construction of diverse compound libraries for drug discovery.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis and molecular recognition studies.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in aromatic systems.

Basic Information

Product Name	3,4-Difluorophenylacetylene
CAS No.	143874-13-9
Molecular Formula	C8H4F2
Molecular Weight	138.12 g/mol
Synonyms	1-Ethynyl-3,4-difluorobenzene; 3,4-Difluoroethynylbenzene; (3,4-Difluorophenyl)acetylene; 3,4-DFPA; 3,4-Difluorobenzeneacetylene; 3,4-Difluorophenyl Ethyne
EINECS	Contact for details

Quality Control

Our 3,4-Difluorophenylacetylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.