Description

Fmoc-Trp(Boc)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of complex peptides and proteins in pharmaceutical research and development. It is primarily used by researchers and manufacturers in the biotechnology and pharmaceutical industries for creating therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the sequential construction of custom peptide sequences.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide tags and linkers used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic Research: Fundamental reagent for studying protein structure, function, and protein-protein interactions.
• Production of GPCR Ligands: Crucial for synthesizing peptides that target G-protein-coupled receptors, a major drug target class.

Basic Information

Item	Detail
Product Name	Fmoc-Trp(Boc)-Oh
CAS No.	143824-78-6
Molecular Formula	C31H30N2O6
Molecular Weight	526.58 g/mol
Synonyms	Fmoc-Tryptophan(Boc)-OH; N-α-Fmoc-N-ω-tert-Butoxycarbonyl-L-tryptophan; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-((tert-butoxycarbonyl)indol-3-yl)propanoic acid; Fmoc-L-Tryptophan(Boc)-OH; Fmoc-Trp(Boc)-OH; N-Fmoc-N'-Boc-L-tryptophan; Fmoc-Trp(Boc)-OH CAS NO 143824-78-6; Boc-Trp(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Trp(Boc)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. For long-term storage, consider storing at 2-8°C under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.