Description

Tokoferol-D6 Acetate CAS NO 143731-16-2 is a deuterium-labeled analog of α-tocopherol acetate, a stable form of Vitamin E. This high-purity, isotopically labeled compound is essential for precise analytical quantification and metabolic studies where standard Vitamin E is used. It serves as a critical internal standard for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and advanced food science industries requiring accurate mass spectrometry analysis.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis of Vitamin E (α-tocopherol) and its acetate form in complex matrices.
• Metabolic tracer studies in pharmacokinetic and pharmacodynamic research for Vitamin E absorption and distribution.
• Quality control and assay validation in the manufacture of pharmaceutical-grade and high-end nutraceutical Vitamin E products.
• Stable isotope dilution analysis (SIDA) for the accurate quantification of tocopherols in food, beverages, and biological fluids.
• Reference material in clinical research investigating Vitamin E deficiency, antioxidant status, and related disorders.
• Use in the development and calibration of analytical methods for compliance with regulatory standards (e.g., USP, EP, FCC).

Basic Information

Product Name	Tokoferol-D6 Acetate
CAS No.	143731-16-2
Molecular Formula	C31H46D6O3
Molecular Weight	~478.75 g/mol
Synonyms	d6-α-Tocopherol Acetate; Deuterated Vitamin E Acetate; (2R,4'R,8'R)-α-Tocopherol-d6 Acetate; 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol-d6 Acetate; Vitamin E-d6 Acetate; All-rac-α-Tocopherol-d6 Acetate; d6-α-Tocopheryl Acetate
EINECS	Contact for details

Quality Control

Our Tokoferol-D6 Acetate is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, and confirmation of structure by NMR and MS. We ensure compliance with relevant standards for research and internal standard use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 98.0 atom % D (by MS)
Solubility	Soluble in ethanol, acetone, chloroform, ether, and oils; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.