Description

N,N'-[(1S,2S)-1,2-Diphenyl-1,2-Ethanediyl]Bis[2-(Diphenylphosphino)-Benzamide is a high-value, chiral bisphosphine ligand with a rigid, well-defined stereochemistry. This compound matters for its exceptional ability to induce high enantioselectivity in transition metal-catalyzed asymmetric reactions, a critical factor in producing single-enantiomer pharmaceuticals and fine chemicals. Industrial researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced material science require this ligand for creating efficient and selective catalytic systems.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for synthesizing chiral active pharmaceutical ingredients (APIs).
• Asymmetric Cross-Coupling Reactions: Employed in C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, to construct complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic production of enantiomerically pure intermediates for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Facilitates the synthesis of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Process R&D: Serves as a benchmark ligand in research laboratories for developing new asymmetric methodologies and optimizing catalytic processes.
• Fine Chemical Production: Applied in the manufacture of specialty flavors, fragrances, and electronic chemicals where high optical purity is required.

Basic Information

Product Name	N,N'-[(1S,2S)-1,2-Diphenyl-1,2-Ethanediyl]Bis[2-(Diphenylphosphino)-Benzamide
CAS No.	143668-57-9
Molecular Formula	C66H52N2O2P2
Molecular Weight	943.07 g/mol
Synonyms	(S,S)-BDPAB; (1S,2S)-N,N'-Bis[2-(Diphenylphosphino)benzoyl]-1,2-Diphenyl-1,2-Ethanediamine; (S,S)-N,N'-Bis(2-(Diphenylphosphino)benzoyl)-1,2-Diphenylethylenediamine; (S,S)-Bisphosphine Amide Benzamide Ligand; (S,S)-BDPAB Ligand; (S,S)-Chiraphos Diamide Derivative; (S,S)-1,2-Bis[(2-Diphenylphosphinophenyl)carbamoyl]-1,2-diphenylethane
EINECS	Contact for details

Quality Control

Our N,N'-[(1S,2S)-1,2-Diphenyl-1,2-Ethanediyl]Bis[2-(Diphenylphosphino)-Benzamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes rigorous analytical testing, including HPLC for chiral purity and assay, 1H/31P/13C NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air or ambient light should be avoided. The storage area should be cool, dry, and well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.