Description

n-(8-Amino-6-Fluoro-5-Methyl-1-Oxo-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-2,2,2-Trifluoro-Acetamide is a high-purity, fluorinated organic intermediate of significant importance in advanced pharmaceutical synthesis. Its complex, multi-functional structure makes it a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. This compound is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of complex, fluorinated drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex, fluorinated drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel APIs where the tetralone and trifluoroacetamide functionalities are required.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: Employed in specialized organic synthesis to introduce fluorine atoms and specific ring systems into target molecules, leveraging its unique reactivity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Item	Details
Product Name	n-(8-Amino-6-Fluoro-5-Methyl-1-Oxo-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-2,2,2-Trifluoro-Acetamide
CAS No.	143655-60-1
Molecular Formula	C₁₃H₁₂F₄N₂O₂
Molecular Weight	304.24 g/mol
Synonyms	2,2,2-Trifluoro-N-(8-amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)acetamide; 8-Amino-6-fluoro-5-methyl-1-oxo-N-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydronaphthalen-2-amine; 143655-60-1; Trifluoroacetamide derivative of amino-fluoro-methyl-tetralone; Fluorinated tetralone acetamide intermediate.
EINECS	Contact for details

Quality Control

Our production of n-(8-Amino-6-Fluoro-5-Methyl-1-Oxo-1,2,3,4-Tetrahydro-Naphthalen-2-Yl)-2,2,2-Trifluoro-Acetamide adheres to stringent quality management systems, ensuring batch-to-batch consistency for research and cGMP manufacturing. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to verify specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.