Description

(4S,5R)-4-Methyl-5-Phenyl-3-Propionyl-2-Oxazolidinone is a high-purity, chiral oxazolidinone derivative widely recognized as a powerful chiral auxiliary in asymmetric synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, ensuring high enantiomeric excess in critical intermediates. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• As a chiral auxiliary in Evans aldol reactions and other asymmetric carbon-carbon bond-forming transformations.
• For the stereocontrolled synthesis of pharmaceutical intermediates, including β-amino acids and other bioactive molecules.
• In the development and scale-up of Active Pharmaceutical Ingredients (APIs) requiring high enantiopurity.
• As a key reagent in academic and industrial research for methodological studies in organic and medicinal chemistry.
• For the preparation of specialty fine chemicals and advanced materials where stereochemistry is critical.

Basic Information

Product Name	(4S,5R)-4-Methyl-5-Phenyl-3-Propionyl-2-Oxazolidinone
CAS No.	143654-01-7
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	(4S,5R)-4-Methyl-5-phenyl-3-propionyl-2-oxazolidinone; (S,R)-4-Methyl-5-phenyl-3-propionyl-2-oxazolidinone; Evans Auxiliary Derivative; N-Propionyl-4-methyl-5-phenyl-2-oxazolidinone; (4S,5R)-3-Propanoyl-4-methyl-5-phenyl-1,3-oxazolidin-2-one; N-Propionyl-(4S,5R)-4-methyl-5-phenyloxazolidin-2-one
EINECS	Contact for details

Quality Control

Our (4S,5R)-4-Methyl-5-Phenyl-3-Propionyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Specified range
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.