Description

Abciximab CAS NO 143653-53-6 is a chimeric monoclonal antibody fragment that functions as a potent glycoprotein IIb/IIIa receptor antagonist. This compound is critical for inhibiting platelet aggregation, a key mechanism in the prevention of thrombotic complications during and after coronary artery procedures. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers and research institutions developing antiplatelet therapies for high-risk percutaneous coronary intervention (PCI) and unstable angina.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of injectable antiplatelet drugs.
• Cardiovascular Therapeutics: Manufacture of medications for the prevention of acute cardiac ischemic complications in patients undergoing percutaneous coronary intervention (PCI).
• Treatment of Unstable Angina: Used in drugs administered to patients not responding to conventional therapy.
• Medical Research: Vital reference standard and biochemical tool for studying platelet physiology, thrombosis mechanisms, and glycoprotein IIb/IIIa receptor function.
• Drug Development: Serves as a key intermediate in the R&D of novel anti-thrombotic agents and biosimilar development programs.

Basic Information

Product Name	Abciximab
CAS No.	143653-53-6
Molecular Formula	C2072H3228N552O669S16
Molecular Weight	~47.6 kDa
Synonyms	Abciximab; c7E3 Fab; Anti-glycoprotein IIb/IIIa monoclonal antibody 7E3 fragment; CentoRx; ReoPro; c7E3; Monoclonal antibody 7E3 Fab fragment; Antiplatelet glycoprotein IIb/IIIa antibody fragment
EINECS	Contact for details

Quality Control

Our Abciximab is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, meeting stringent specifications for pharmaceutical active ingredients. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with relevant internal quality standards. We support development and commercial projects requiring material produced under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be used immediately or stored as directed by the specific product protocol. Store in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE / SEC-HPLC)	≥ 95.0%
Potency (Platelet Aggregation Inhibition Assay)	Conforms to reference
Protein Content (UV Absorbance)	Conforms to label claim
Endotoxin (LAL test)	< 1.0 EU/mg
Residual Moisture (Karl Fischer)	< 5.0%
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.