Description

Carbamic Acid, [2-Amino-1-(Aminomethyl)-2-Oxoethyl]-, 1,1-Dimethylethyl Ester is a protected amino acid derivative, specifically a tert-butyloxycarbonyl (Boc)-protected diaminopropionic acid analog, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing orthogonal protection for amino groups, enabling the precise and sequential construction of complex peptides and other bioactive molecules. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, peptide-based therapeutics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected diaminopropionic acid (Dap) derivative to introduce specific side-chain functionalities.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) group provides acid-labile protection for amines, crucial for multi-step synthetic sequences.
• Bioconjugation & Linker Chemistry: Serves as a precursor for constructing specialized linkers and spacers in antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Employed in academic and industrial R&D labs for exploring new chemical entities and developing novel synthetic methodologies.
• Fine Chemical Production: Integral to the manufacture of high-value, custom-designed fine chemicals and specialty materials.

Basic Information

Item	Details
Product Name	Carbamic Acid, [2-Amino-1-(Aminomethyl)-2-Oxoethyl]-, 1,1-Dimethylethyl Ester
CAS No.	143634-52-0
Molecular Formula	C9H18N2O4
Molecular Weight	218.25 g/mol
Synonyms	Boc-Dap-OH; Nα-Boc-L-2,3-diaminopropionic acid; (S)-2-((tert-Butoxycarbonyl)amino)-3-aminopropanoic acid; tert-Butyl (2-amino-1-carboxyethyl)carbamate; Boc-L-Dap-OH; N-Boc-L-2,3-diaminopropanoic acid; Boc-2,3-diaminopropionic acid; 2,3-Diaminopropionic acid Boc derivative
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [2-Amino-1-(Aminomethyl)-2-Oxoethyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.