Description

Erythromycin Hydrolyzed Metabolite CAS NO 143416-84-6 is a key intermediate and reference standard derived from the metabolic breakdown of the macrolide antibiotic erythromycin. This compound is of significant importance for pharmaceutical research, quality control, and analytical method development. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories involved in antibiotic metabolism studies, impurity profiling, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of erythromycin-related impurities and degradation products in drug substances and finished products.
• Metabolism and Pharmacokinetic Studies: Serves as a critical metabolite standard in in vitro and in vivo studies to understand the metabolic pathways and pharmacokinetic profile of erythromycin.
• Analytical Method Development: Essential for developing and validating high-performance liquid chromatography (HPLC), LC-MS, and other chromatographic methods for antibiotic analysis.
• Impurity Profiling and Control: Employed in quality control laboratories to monitor and control specified and unspecified impurities in erythromycin API and formulations as per ICH guidelines.
• Research Chemical: Used as a building block or intermediate in synthetic organic chemistry for the research and development of new macrolide derivatives or prodrugs.
• Regulatory Compliance Testing: Supports compliance testing for regulatory submissions (e.g., to FDA, EMA) requiring detailed impurity characterization and control strategies.

Basic Information

Product Name	Erythromycin Hydrolyzed Metabolite
CAS No.	143416-84-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Erythromycin Hydrolysis Metabolite; Erythromycin Degradant; Erythromycin Related Compound; Erythromycin Impurity; (8S,9R,10R,11R,12R,13S,14R)-9-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-11-one (possible IUPAC); Erythromycin Metabolite Standard; Macrolide Metabolite; Antibiotic Reference Standard.
EINECS	Contact for details

Quality Control

Our Erythromycin Hydrolyzed Metabolite is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and analytical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.