Description

Boc-2-Methoxy-L-Phenylalanine is a protected derivative of the non-natural amino acid L-2-Methoxyphenylalanine, featuring a tert-butoxycarbonyl (Boc) group on the amine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide synthesis. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers developing novel therapeutic agents, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the research and development of peptide-based pharmaceuticals and bioactive molecules.
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) and solution-phase methods to incorporate the 2-methoxyphenylalanine residue into peptide chains.
• Protease Inhibitor Development: Serves as a core component in the design and synthesis of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the structure-activity relationships (SAR) of peptides.
• GPCR Ligand Synthesis: Used in the preparation of peptide ligands for G-protein-coupled receptors (GPCRs) due to the aromatic methoxy modification.
• Fine Chemical Production: An important building block for custom synthesis services and the production of non-standard amino acid derivatives.

Basic Information

Item	Details
Product Name	Boc-2-Methoxy-L-Phenylalanine
CAS No.	143415-63-8
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(2-methoxyphenyl)propanoic acid; N-(tert-Butoxycarbonyl)-2-methoxy-L-phenylalanine; Boc-L-2-Methoxyphenylalanine; Boc-2-MeO-L-Phe-OH; N-Boc-2-methoxy-L-phenylalanine; tert-Butyl (2S)-2-amino-3-(2-methoxyphenyl)-1-oxopropan-2-ylcarbamate; BOC-2-METHOXY-L-PHE
EINECS	Contact for details

Quality Control

Our Boc-2-Methoxy-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.