Description

5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylic Acid, 7-(((1-(4-Bromo Phenyl)Cyclopentyl)Carbonyl)Amino)-3-Methyl-8-Oxo-, Monosodium Salt, ( 6R-Trans)- is a high-purity, advanced pharmaceutical intermediate with a complex bicyclic β-lactam core structure. This compound is critical for the synthesis of novel cephalosporin antibiotics, offering a key building block for research and development into next-generation antimicrobial agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and antibiotic discovery.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research, development, and synthesis of novel cephalosporin-class antibiotics.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies to develop new antibacterial agents with improved efficacy and spectrum.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, high-value target molecules in a GMP or non-GMP environment.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control testing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating bacterial resistance mechanisms and the mode of action of β-lactam antibiotics.

Basic Information

Product Name	5-Thia-1-Azabicyclo(4.2.0)Oct-2-Ene-2-Carboxylic Acid, 7-(((1-(4-Bromo Phenyl)Cyclopentyl)Carbonyl)Amino)-3-Methyl-8-Oxo-, Monosodium Salt, ( 6R-Trans)-
CAS No.	143407-75-4
Molecular Formula	C21H22BrN3NaO5S
Molecular Weight	522.38 g/mol
Synonyms	(6R,7R)-7-[[(1-(4-Bromophenyl)cyclopentyl)carbonyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt; Sodium (6R,7R)-7-[(1-(4-bromophenyl)cyclopentanecarboxamido)]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cephalosporin derivative intermediate; 4-Bromo substituted cephalosporin sodium salt; 143407-75-4; BRP-CP-AM-3M-8O-5T-1A-OC-2E-2C-ACID Na Salt
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for pharmaceutical research. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as assay, related substances, and residual solvents. While produced under controlled conditions, specific compliance with GMP, ICH Q7, or other regulatory guidelines can be discussed and tailored to project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.