Description

Acetamide, 2,2,2-Trifluoro-n-(2-Iodophenyl)- is a specialized fluorinated and iodinated acetamide derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both trifluoromethyl and ortho-iodophenyl substituents, makes it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology, where the trifluoromethyl group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the iodine atom for further functionalization via cross-coupling reactions.
• Material Science Research: Serves as a monomer or functional additive in the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes, where the iodine serves as a handle for radiolabeling (e.g., with I-125).
• Catalyst & Ligand Development: Acts as a precursor for creating novel palladium ligands or organocatalysts used in asymmetric synthesis and cross-coupling reactions.

Basic Information

Product Name	Acetamide, 2,2,2-Trifluoro-n-(2-Iodophenyl)-
CAS No.	143321-89-5
Molecular Formula	C9H7F3INO
Molecular Weight	329.06 g/mol
Synonyms	2,2,2-Trifluoro-N-(2-iodophenyl)acetamide; N-(2-Iodophenyl)-2,2,2-trifluoroacetamide; 2-Iodo-2',2',2'-trifluoroacetanilide; o-Iodo-α,α,α-trifluoroacetanilide; TFIA (common abbreviation); 2,2,2-Trifluoroacet-2'-iodoanilide; N-(2-Iodophenyl)trifluoroacetamide
EINECS	Contact for details

Quality Control

Every batch of Acetamide, 2,2,2-Trifluoro-n-(2-Iodophenyl)- undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR, NMR), and impurity profile is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.