Description

Neurofilament Protein Nf 70 is a high-purity, specialized protein component of the neuronal cytoskeleton. This product is critical for advanced biomedical research, particularly in the study of neuronal structure, axonal transport, and neurodegenerative diseases. It is an essential reagent for neuroscientists, diagnostic developers, and pharmaceutical researchers focusing on biomarkers for conditions such as amyotrophic lateral sclerosis (ALS), Alzheimer's, and traumatic brain injury.

Application

• Biomarker Research: Used as a standard and antigen in the development and validation of immunoassays (ELISA, Western Blot) for detecting neurofilament levels in cerebrospinal fluid (CSF) and blood serum, a key indicator of neuronal damage.
• Neurodegenerative Disease Studies: Essential for in vitro models and experimental studies investigating the pathogenesis of ALS, multiple sclerosis (MS), Parkinson's disease, and other neurological disorders.
• Diagnostic Kit Development: Serves as a critical raw material for manufacturers producing clinical diagnostic kits for neurological injury and disease monitoring.
• Antibody Production & Validation: Acts as an immunogen for generating specific monoclonal or polyclonal antibodies, and as a control for testing antibody specificity and sensitivity.
• Cell Biology & Neuroscience: Utilized in fundamental research on neurofilament assembly, axonal caliber regulation, and intracellular transport mechanisms within neurons.
• Pharmaceutical R&D: Applied in drug discovery programs targeting neuroprotection or therapies aimed at modulating neurofilament expression and phosphorylation.

Basic Information

Product Name	Neurofilament Protein Nf 70
CAS No.	143221-02-7
Molecular Formula	Contact for details
Molecular Weight	~70 kDa (Protein)
Synonyms	Neurofilament 70 kDa Protein; NF-L (Neurofilament Light Chain); Neurofilament Triplet L Protein; NFL; NF70; Neuronal Intermediate Filament Protein NF-L; Neurofilament Light Polypeptide; Neurofilament Protein, Light Chain
EINECS	Contact for details

Quality Control

Our Neurofilament Protein Nf 70 is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is subjected to rigorous purity analysis and functional testing. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as purity (by SDS-PAGE), identity (by immunoreactivity), concentration, and endotoxin levels. Our quality system is designed to support research and in-vitro diagnostic (IVD) development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot upon receipt for single-use to maintain optimal activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solution
Identification (Immunoblot)	Reacts with specific anti-NF-L antibodies
Purity (SDS-PAGE)	≥ 90%
Protein Concentration	As per COA (typically 0.1-1.0 mg/mL)
Biological Activity	Suitable for use in ELISA/Western Blot
Endotoxin Level	< 1.0 EU/μg (for cell culture grade)
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.