Description

Transcription Factor Pml CAS NO 143220-95-5 is a high-purity biochemical reagent critical for advanced life science research and pharmaceutical development. This compound serves as a key regulatory protein involved in cellular processes such as apoptosis, senescence, and tumor suppression, making it an essential tool for studying oncogenic pathways and potential therapeutic targets. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical R&D departments focused on cancer biology, gene regulation, and molecular diagnostics.

Application

• Biomedical Research: Fundamental studies on the role of PML nuclear bodies in cellular senescence, apoptosis, and antiviral defense mechanisms.
• Oncology & Cancer Research: Investigation of PML's function as a tumor suppressor protein and its interactions in leukemogenesis and solid tumors.
• Drug Discovery & Target Validation: Used in high-throughput screening assays and as a reference standard to identify and validate novel compounds targeting PML-related pathways.
• Molecular Biology Reagent: Essential component in protein-protein interaction studies, co-immunoprecipitation (Co-IP), and Western blotting as a control or target protein.
• Diagnostic Development: Potential use in developing diagnostic assays for cancers where PML expression or fusion proteins (e.g., PML-RARα) are relevant biomarkers.
• Cell Signaling Studies: Research into post-translational modifications of PML, such as SUMOylation, and its impact on transcriptional regulation and signal transduction.

Basic Information

Product Name	Transcription Factor Pml
CAS No.	143220-95-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PML Protein; Promyelocytic Leukemia Protein; Tripartite Motif-Containing Protein 19 (TRIM19); RING Finger Protein 71 (RNF71); Myeloid Nuclear Differentiation Antigen; PP8675; PML Tumor Suppressor; Nuclear Body Protein PML
EINECS	Contact for details

Quality Control

Our Transcription Factor Pml is produced under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to rigorous analytical testing, including purity assessment, identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing specific results for purity, endotoxin levels, and biological activity are provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, aliquots are recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Conforms
Purity (SDS-PAGE)	≥ 90%
Protein Content (BCA)	≥ 95% of stated mass
Endotoxin Level (LAL)	< 1.0 EU/µg
Biological Activity	Assay-dependent; COA provided
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.