Description

Granzyme B is a serine protease enzyme that plays a critical role in the immune system's cytotoxic response. Its primary function is to induce apoptosis in target cells, making it a key molecule of interest in immunological research and therapeutic development. This product is essential for researchers and developers in the fields of oncology, autoimmune disease research, and immunotherapy, particularly for studying cell death pathways and developing novel treatments.

Application

• Immunological Research: Fundamental studies on cytotoxic T lymphocyte (CTL) and natural killer (NK) cell-mediated apoptosis.
• Cancer Research: Investigation of tumor cell resistance mechanisms and development of cancer immunotherapies.
• Autoimmune Disease Studies: Research into diseases where dysregulated granzyme B activity contributes to pathology.
• Drug Discovery & Screening: Used as a target enzyme for high-throughput screening of potential inhibitors for therapeutic applications.
• Biomarker Development: Utilized in the development of assays to detect granzyme B activity as a biomarker for immune activation.
• In vitro Diagnostic (IVD) Reagent Production: A key component in the manufacture of research-grade ELISA kits and activity assays.

Basic Information

Product Name	Granzyme B
CAS No.	143180-74-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Granzyme-2; Cytotoxic T-lymphocyte proteinase 2; CTLA-2; C11; Fragmentin-2; Hanukkah factor; Granzyme B (human lymphocyte proteinase); T-cell serine protease 1-3E; CCP1; CGL1; CTSGL1
EINECS	Contact for details

Quality Control

Our Granzyme B is produced and tested under stringent conditions to ensure high purity and consistent biological activity, suitable for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, activity, and sterility data. We adhere to rigorous quality management principles to support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. For extended storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (SDS-PAGE)	> 95%
Specific Activity	> 20 units/mg protein
Endotoxin Level (LAL)	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.