Description

Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-Nitro-Tyr-Asp-Oh is a synthetic peptide sequence containing a 3-nitrotyrosine residue, a key marker for oxidative stress and nitrosative damage in biological systems. This compound matters as a critical research tool for studying protein tyrosine nitration, enzyme inhibition, and the biochemical pathways associated with inflammatory and neurodegenerative diseases. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on proteomics, biomarker discovery, and drug development. The peptide's specific sequence and modification make it valuable for assay development, antibody production, and as a reference standard in analytical chemistry.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate protease activity and specificity.
• Proteomics & Biomarker Discovery: Serves as a reference standard for the detection and quantification of 3-nitrotyrosine in proteins, a hallmark of oxidative stress.
• Antibody Production: Acts as a hapten for generating specific antibodies against nitrotyrosine-containing epitopes for use in ELISA, Western blot, and immunohistochemistry.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify potential therapeutic compounds that modulate nitration pathways.
• Academic Studies: Utilized in university and institutional labs to model post-translational modifications and their role in cell signaling and disease pathology.
• Diagnostic Kit Development: Incorporated as a key component in the development of diagnostic assays for conditions involving oxidative damage, such as cardiovascular and neurological disorders.

Basic Information

Product Name	Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-Nitro-Tyr-Asp-Oh
CAS No.	143147-74-4
Molecular Formula	C68H81N13O22
Molecular Weight	1472.43 g/mol
Synonyms	Abz-AFAPFDVFY(NO2)D-OH; 2-Aminobenzoyl-Ala-Phe-Ala-Phe-Asp-Val-Phe-Tyr(3-NO2)-Asp-OH; FRET Substrate Peptide Abz-AFAPFDVFY(NO2)D; Nitrotyrosine-containing Peptide Substrate; 3-Nitrotyrosyl Peptide; Abz-AFAPFDVFY(3-NO2)D; Oxidative Stress Marker Peptide; Protease Fluorescent Substrate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade peptides. Each batch is characterized using advanced analytical techniques including HPLC and mass spectrometry to verify identity, purity, and correct molecular weight. Certificates of Analysis (COA) are available upon request, providing detailed data on purity, amino acid analysis, and peptide content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.