Description

Boc-L-Cyclohexylalanine Hydroxysuccinimide Ester is a high-purity, protected amino acid active ester derivative designed for efficient peptide synthesis. This compound serves as a critical building block, enabling the controlled and selective incorporation of the non-proteinogenic amino acid, L-cyclohexylalanine, into peptide chains under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise molecular construction.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, sequential assembly of peptides, particularly for introducing the hydrophobic Cha residue.
• Solution-Phase Peptide Coupling: Used in classical solution methods for synthesizing peptide fragments and small cyclic peptides.
• Pharmaceutical Intermediate: Critical for the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with peptides or tags.
• Peptidomimetic Research: Employed in the development of peptide analogs and mimetics with enhanced stability or biological activity.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	Boc-L-Cyclohexylalanine Hydroxysuccinimide Ester
CAS No.	143118-52-9
Molecular Formula	C18H28N2O6
Molecular Weight	368.43 g/mol
Synonyms	Boc-Cha-OSu; N-(tert-Butoxycarbonyl)-L-cyclohexylalanine N-hydroxysuccinimide ester; Nα-Boc-L-cyclohexylalanine N-succinimidyl ester; Boc-L-2-Cyclohexylalanine N-hydroxysuccinimide ester; (2S)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3-cyclohexylpropanoic acid 2,5-dioxopyrrolidin-1-yl ester; N-Boc-L-cyclohexylalanine succinimidyl ester; Boc-L-Cha-OSu; Boc-L-Cyclohexyl-Ala-OSu
EINECS	Contact for details

Quality Control

Every batch of Boc-L-Cyclohexylalanine Hydroxysuccinimide Ester is produced and tested under strict quality management systems. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. Comprehensive analytical testing, including HPLC for purity and chiral integrity, is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.