Description

Cap18 Lipopolysaccharide-Binding Protein is a synthetic cationic antimicrobial peptide designed to bind and neutralize bacterial endotoxins. This compound is critical for research and development in fields requiring precise control over Gram-negative bacterial components and their inflammatory responses. It is primarily utilized by researchers in immunology, microbiology, and pharmaceutical development for studying sepsis mechanisms, developing anti-infective therapies, and creating advanced diagnostic assays.

Application

• Sepsis and Endotoxin Research: Used as a key reagent to study the binding and neutralization of lipopolysaccharide (LPS) in models of septic shock and systemic inflammation.
• In-Vitro Diagnostic Development: Incorporated into assay kits (e.g., LAL tests) for the specific detection and quantification of bacterial endotoxins in pharmaceutical products and medical devices.
• Antimicrobial Peptide Studies: Serves as a reference standard or active compound in research exploring the structure-activity relationship of cationic antimicrobial peptides (CAPs).
• Drug Discovery Platforms: Employed in high-throughput screening to identify novel compounds that modulate the TLR4 signaling pathway activated by LPS.
• Biomaterial and Implant Coating: Investigated for surface functionalization to create anti-endotoxic coatings on medical implants to reduce biofilm formation and inflammatory responses.
• Vaccine Adjuvant Research: Studied for its potential to modulate immune responses when used in conjunction with vaccine antigens.

Basic Information

Product Name	Cap18 Lipopolysaccharide-Binding Protein
CAS No.	143108-26-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CAP18; Cationic Antimicrobial Protein 18; LL-37 (human cathelicidin fragment); FALL-39; Antimicrobial Peptide CAP18; Lipopolysaccharide Binding Peptide; Endotoxin Neutralizing Peptide; Synthetic CAP18
EINECS	Contact for details

Quality Control

Our Cap18 Lipopolysaccharide-Binding Protein is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant quality management standards to support our commitment to supplying reliable research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Endotoxin Content (LAL)	< 1.0 EU/mg
Biological Activity (LPS Neutralization)	Confirmed by cell-based assay
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.