Description

(S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(T-Butyl) Ester CAS NO 143106-46-1 is a high-purity, chiral protected intermediate of significant value in advanced organic synthesis. This compound is specifically designed for the controlled introduction of a metal-chelating EDTA moiety into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapeutics, diagnostic imaging agents, and novel chelating polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing targeted radiopharmaceuticals and MRI contrast agents.
• Bifunctional Chelator (BFC) Precursor: Used to create conjugates that link radioactive isotopes (e.g., Technetium-99m, Lutetium-177) or gadolinium to antibodies, peptides, or other targeting molecules.
• Research Chemical: Employed in academic and industrial R&D for studying metal ion coordination chemistry and developing new diagnostic tools.
• Polymer Modification: Serves as a functional monomer or cross-linker for creating smart materials with metal-binding capabilities.
• Ligand Synthesis: Precursor for advanced chiral ligands used in asymmetric catalysis and separation sciences.

Basic Information

Product Name	(S)-4-Aminobenzyl Ethylenediaminetetraacetic Acid Tetra(T-Butyl) Ester
CAS No.	143106-46-1
Molecular Formula	C33H55N3O8
Molecular Weight	621.81 g/mol
Synonyms	(S)-4-Aminobenzyl-EDTA-tetra(t-butyl) ester; (S)-p-Aminobenzyl-EDTA-tetra-tert-butyl ester; (S)-ABn-EDTA-tBu4; EDTA-(S)-4-Aminobenzyl tetra-tert-butyl ester; (S)-1-(4-Aminobenzyl)-4,7,10-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tetra-tert-butyl ester (related structural name); (S)-ABn-DOTA-tBu4 (common misnomer for EDTA analog); Bifunctional Chelator t-butyl ester; Chiral EDTA protected ester.
EINECS	Contact for details

Quality Control

Our (S)-4-Aminobenzyl EDTA Tetra(T-Butyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.