Description

8-Methylguanine 7-Oxide is a modified purine nucleobase derivative of significant interest in biochemical research. This compound serves as a critical reference standard and synthetic intermediate for studying nucleic acid damage, repair mechanisms, and oxidative stress pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, toxicology, and molecular biology to investigate mutagenesis and develop novel therapeutic agents.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the quantification and identification of oxidative DNA damage products in biological samples.
• Oncology & Toxicology Studies: Essential for research into the mechanisms of carcinogenesis and the biological impact of environmental mutagens.
• Nucleic Acid Chemistry: Serves as a key synthetic building block for the preparation of modified oligonucleotides and probes.
• Enzyme Substrate & Inhibitor Studies: Employed in assays to study the activity and specificity of DNA repair enzymes like glycosylases.
• Diagnostic Development: Potential use in the development of diagnostic kits for detecting oxidative stress biomarkers.
• Pharmaceutical Intermediate: Acts as a precursor in the synthesis of novel nucleoside analogs with potential therapeutic applications.

Basic Information

Product Name	8-Methylguanine 7-Oxide
CAS No.	143101-66-0
Molecular Formula	C₆H₇N₅O₂
Molecular Weight	181.15 g/mol
Synonyms	7-Hydroxy-8-methylguanine; 8-Methyl-7-oxoguanine; 8-Methylguanine-7-oxide; Guanine, 8-methyl-7-oxide; 8-Methyl-7-hydroxyguanine; 8-MeGua-7-oxide; 8-Methyl-7(8H)-guaninone
EINECS	Contact for details

Quality Control

Every batch of 8-Methylguanine 7-Oxide is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.