Description

Anakinra is a recombinant, non-glycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra), a critical protein that modulates inflammatory responses. This product is essential for research and development in immunology and the production of targeted biologic therapies. It is primarily utilized by pharmaceutical manufacturers, biotechnology research institutions, and academic laboratories focused on autoimmune and inflammatory diseases.

Application

• Active Pharmaceutical Ingredient (API): Serves as the core biologic component in the formulation of finished drug products.
• Biopharmaceutical Research: Used as a reference standard and experimental reagent in studies of interleukin-1 (IL-1) pathway biology and signal transduction.
• Drug Discovery & Development: Employed in preclinical and clinical-stage programs targeting autoimmune disorders such as rheumatoid arthritis.
• Process Development & Scale-Up: Critical for optimizing fermentation, purification, and formulation processes in biomanufacturing.
• Quality Control & Analytical Testing: Functions as a purity standard in assays like HPLC and electrophoresis to ensure batch consistency.

Basic Information

Product Name	Anakinra
CAS No.	143090-92-0
Molecular Formula	C759H1186N208O232S10
Molecular Weight	~17.3 kDa
Synonyms	Recombinant Human IL-1Ra; rhIL-1Ra; IL1RN; Interleukin-1 Receptor Antagonist Protein; Antril; Kinaret; r-metHuIL-1ra; IL-1 inhibitor
EINECS	Contact for details

Quality Control

Our Anakinra is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and safety, aligning with ICH Q6B guidelines for biotechnological products. A detailed Certificate of Analysis (COA) providing results for purity (by HPLC), biological activity, endotoxin levels, and other critical attributes is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Biological Activity (Cell-based assay)	≥ 1 x 10^7 units/mg
Endotoxin	< 1.0 EU/mg
Protein Content (UV)	Conforms to label claim
Residual Moisture (KFT)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.