Description

(Ac-D-Trp16)-Endothelin-1 (16-21) is a synthetic, biologically active peptide fragment derived from the potent vasoconstrictor Endothelin-1, featuring a key D-tryptophan substitution and acetylation at position 16. This modification enhances its metabolic stability and receptor selectivity, making it a critical tool for advanced pharmacological research and drug discovery. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cardiovascular biology, receptor-ligand interaction studies, and the development of novel therapeutic agents targeting the endothelin system.

Application

• Biochemical Research: A key reference standard and tool for studying endothelin receptor (ETA/ETB) binding affinity, selectivity, and signal transduction mechanisms.
• Pharmaceutical Development: Used in the screening and characterization of new endothelin receptor antagonists for treating conditions like pulmonary arterial hypertension and chronic kidney disease.
• Structure-Activity Relationship (SAR) Studies: The acetylated D-Trp modification provides a stable model for investigating how peptide backbone alterations affect biological activity and stability.
• In Vitro & Ex Vivo Assays: Employed in vascular tissue bath experiments and cell-based assays to measure vasoconstrictive responses and cellular calcium flux.
• Peptide Chemistry & Conjugation: Serves as a specialized building block or intermediate for synthesizing more complex peptide conjugates or probes labeled with fluorophores or other tags.

Basic Information

Product Name	(Ac-D-Trp16)-Endothelin-1 (16-21)
CAS No.	143037-33-6
Molecular Formula	C41H56N10O10
Molecular Weight	848.96 g/mol
Synonyms	Ac-[D-Trp16]-Endothelin-1(16-21); N-Acetyl-D-tryptophanyl-L-leucyl-L-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan; Ac-D-Trp-Leu-Asp-Ile-Ile-Trp; Ac-D-Trp16-ET-1(16-21); [D-Trp16,Ac]-Endothelin-1 (16-21); Endothelin-1 (16-21) fragment, Ac-D-Trp16 analog; ET-1 (16-21), Ac-D-Trp16
EINECS	Contact for details

Quality Control

Every batch of (Ac-D-Trp16)-Endothelin-1 (16-21) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing results from HPLC, MS, and NMR are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95% (Area Percent)
Assay (HPLC)	≥90% (on anhydrous basis)
Water Content (KF)	≤5.0%
Single Impurity (HPLC)	≤2.0%
Peptide Content	≥70%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.