Description

Boc-L-3-Trifluoromethylphe CAS NO 142995-31-1 is a high-purity, protected amino acid derivative featuring a trifluoromethyl group on the phenylalanine side chain. This compound is a critical building block in modern pharmaceutical research and development, particularly for the synthesis of peptide-based drugs and bioactive molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries to introduce fluorine atoms, which can dramatically alter a molecule's metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide therapeutics and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate fluorinated phenylalanine analogs.
• Medicinal Chemistry: Serves as a building block for creating compound libraries in drug discovery programs targeting metabolic diseases and CNS disorders.
• Agrochemical Research: Employed in the development of advanced pesticides and herbicides where fluorine substitution enhances bioactivity.
• Bioconjugation: Useful for modifying peptides and proteins to study structure-activity relationships (SAR).
• Chemical Biology Probes: Acts as a precursor for labeled amino acids used in imaging and diagnostic applications.

Basic Information

Product Name	Boc-L-3-Trifluoromethylphe CAS NO 142995-31-1
CAS No.	142995-31-1
Molecular Formula	C₁₅H₁₈F₃NO₄
Molecular Weight	333.31 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid; Boc-3-CF3-Phe-OH; N-Boc-3-Trifluoromethyl-L-phenylalanine; N-(tert-Butoxycarbonyl)-3-(trifluoromethyl)-L-phenylalanine; Boc-L-3-(Trifluoromethyl)phenylalanine; tert-Butyloxycarbonyl-3-trifluoromethyl-L-phenylalanine; Boc-L-Phe(3-CF3)-OH; Nα-Boc-3-Trifluoromethyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-L-3-Trifluoromethylphe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring compliance with the rigorous standards required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.