Description

(R)-n-Fmoc-(3-Pyridyl)Alanine is a non-natural, chiral amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a pyridyl side chain with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools where structural diversity and chiral purity are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to modulate bioactivity, stability, and receptor binding affinity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Ligand Development: Creation of peptides with metal-chelating pyridyl groups for catalytic or sensing applications.
• Academic Research: Fundamental studies in organic synthesis, asymmetric synthesis, and amino acid chemistry.

Basic Information

Product Name	(R)-n-Fmoc-(3-Pyridyl)Alanine
CAS No.	142994-45-4
Molecular Formula	C22H18N2O4
Molecular Weight	374.39 g/mol
Synonyms	Fmoc-(R)-3-(3-Pyridyl)-alanine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-pyridinyl)-D-alanine; Fmoc-D-3-Pyridylalanine; Fmoc-3-Pal(3)-OH; (R)-N-Fmoc-3-(3-Pyridyl)alanine; N-α-Fmoc-3-(3-pyridinyl)-D-alanine
EINECS	Contact for details

Quality Control

Our (R)-n-Fmoc-(3-Pyridyl)Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, to ensure it meets the high standards required for peptide synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.