Description

2,2-Difluoro-3-Phenylpropanoic Acid CAS NO 142977-64-8 is a high-value fluorinated aromatic building block characterized by its difluoromethyl group adjacent to a carboxylic acid. This compound is essential for introducing fluorine atoms into target molecules, a key strategy in modern medicinal chemistry to modulate bioavailability, metabolic stability, and binding affinity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates where fluorine substitution is desired.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging fluorine's ability to enhance lipophilicity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, exploiting the unique electronic properties of the difluoromethylene group.
• Fluorine Chemistry: A versatile starting material for further derivatization, including esterification, amidation, and reduction reactions to create a library of fluorinated compounds.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for coupling to biomolecules, making it useful in creating fluorescent probes or labeled compounds for diagnostic research.

Basic Information

Product Name	2,2-Difluoro-3-Phenylpropanoic Acid
CAS No.	142977-64-8
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2,2-Difluoro-3-phenylpropionic acid; 3-Phenyl-2,2-difluoropropanoic acid; α,α-Difluoro-β-phenylpropionic acid; 2,2-Difluoro-3-phenylpropanoate; DFPPA; β-Phenyl-α,α-difluoropropionic acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-3-Phenylpropanoic Acid is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to support your cGMP or research-grade projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.