Description

1-Iodo-3,3,3-trifluoroacetone is a specialized fluorinated and iodinated building block of significant interest in advanced organic synthesis. This compound matters for its unique reactivity profile, combining the electrophilic character of the carbonyl and iodo groups with the stability and lipophilicity imparted by the trifluoromethyl moiety. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the synthesis of fluorinated analogs and as a precursor for further functionalization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the CF3 group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique surface properties.
• Ligand and Catalyst Development: Employed in the preparation of novel organometallic complexes and catalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A versatile reagent for studying nucleophilic substitution and addition reactions in fluorinated systems.
• Radiopharmaceutical Labeling: The iodine atom provides a potential handle for radioiodination in diagnostic imaging agent development.

Basic Information

Item	Detail
Product Name	1-Iodo-3,3,3-trifluoroacetone
CAS No.	142921-30-0
Molecular Formula	C4H2F3IO
Molecular Weight	249.96 g/mol
Synonyms	3,3,3-Trifluoro-1-iodoacetone; 3,3,3-Trifluoro-1-iodopropan-2-one; 1-Iodo-3,3,3-trifluoropropan-2-one; 3,3,3-Trifluoro-2-propanone, 1-iodo-; Iodotrifluoroacetone; TFIA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-Iodo-3,3,3-trifluoroacetone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and spectroscopic identification, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Due to its highly volatile nature, ensure containers are securely sealed and handled in a fume hood.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.