Description

Blonanserin n-Oxide is a key pharmaceutical intermediate and metabolite of the antipsychotic agent blonanserin. This compound is of significant importance for research and development in neuropharmacology, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) who are involved in the synthesis, quality control, and regulatory submission processes for neuropsychiatric therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of blonanserin and its related substances in drug products and biological matrices.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, bioavailability, and clearance mechanisms of the parent drug blonanserin.
• Impurity Profiling: Used as an identified impurity standard to monitor and control the quality of blonanserin API during manufacturing, ensuring compliance with ICH guidelines on impurities in new drug substances.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for pharmacokinetic and bioequivalence studies.
• Preclinical & Clinical Studies: Employed in toxicological assessments and clinical trials to understand the safety profile of blonanserin's oxidative metabolites.
• Chemical Synthesis Intermediate: Can be utilized in the synthetic pathway for producing novel blonanserin analogs or for degradation studies.

Basic Information

Product Name	Blonanserin n-Oxide
CAS No.	142838-82-2
Molecular Formula	C23H30FN3O2
Molecular Weight	399.51 g/mol
Synonyms	2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-9-one 1-Oxide; Blonanserin N-Oxide; Blonanserin Metabolite; AD-5423 n-Oxide; Blonanserin 1-Oxide; 4-(4-Fluorophenyl)-2-(4-ethylpiperazin-1-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-9-one 1-oxide
EINECS	Contact for details

Quality Control

Our Blonanserin n-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual unknown impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.