Description

Bombesin(6-14), Tpi(6)-Leu(13)-Psi(Ch2N)-Tpi(14)- CAS NO 142824-94-0 is a synthetic peptide analog derived from the C-terminal fragment of the neuropeptide bombesin, featuring a reduced peptide bond (Psi) modification. This compound is a potent and selective antagonist for bombesin receptor subtypes, making it a critical research tool for studying neuropeptide signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurobiology, oncology, and metabolic disorder research.

Application

• Biomedical Research: As a selective receptor antagonist for investigating the physiological roles of bombesin and gastrin-releasing peptide (GRP) in cellular signaling.
• Oncology Studies: Used in preclinical research to probe the involvement of bombesin receptors in tumor growth and proliferation, particularly in cancers of the lung, prostate, and pancreas.
• Neuropharmacology: A key reagent for studying central nervous system functions, including satiety, thermoregulation, and stress responses mediated by bombesin-like peptides.
• Drug Discovery: Serves as a reference standard and a lead compound in the development of novel therapeutic agents targeting GPCRs (G-protein-coupled receptors).
• In Vitro Diagnostics: Used in the development and validation of competitive binding assays (e.g., RIA, ELISA) to quantify receptor-ligand interactions.
• Metabolic Research: Applied in studies exploring the role of bombesin in gastrointestinal function and energy homeostasis.

Basic Information

Product Name	Bombesin(6-14), Tpi(6)-Leu(13)-Psi(Ch2N)-Tpi(14)-
CAS No.	142824-94-0
Molecular Formula	C58H84N16O11
Molecular Weight	1181.4 g/mol
Synonyms	Bombesin (6-14), [Tpi6, Leu13 psi(CH2NH)Tpi14]-; [D-Tpi6, Leu13 psi(CH2NH)Leu14]Bombesin(6-14); Bombesin Receptor Antagonist; BW 2258U89; BW-2258U89; GRP Receptor Antagonist; Pseudopeptide Bombesin Analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of Bombesin(6-14), Tpi(6)-Leu(13)-Psi(Ch2N)-Tpi(14)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis to specific purity levels (typically >95% to >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.