Description

S-(+)-o-Desmethyl Venlafaxine is a high-purity chiral intermediate and active metabolite of the antidepressant venlafaxine. This compound is of significant value for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and for use as a reference standard in analytical testing. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development, quality control, and bioequivalence studies of serotonin-norepinephrine reuptake inhibitors (SNRIs).

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel or generic antidepressant APIs.
• Reference Standard: Certified reference material (CRM) for quality control and assay validation in pharmaceutical manufacturing.
• Metabolite Standard: Essential for pharmacokinetic, pharmacodynamic, and bioanalytical studies in clinical and preclinical research.
• Analytical Research: Used in method development and impurity profiling for HPLC, LC-MS, and other chromatographic techniques.
• Process Chemistry: Serves as a critical intermediate in optimizing and scaling up enantioselective synthesis routes.
• Regulatory Submissions: Provides necessary data and materials for drug master files (DMFs) and regulatory compliance documentation.

Basic Information

Product Name	S-(+)-o-Desmethyl Venlafaxine
CAS No.	142761-12-4
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	(S)-o-Desmethylvenlafaxine; (S)-O-Desmethyl Venlafaxine; (1S)-2-(Dimethylamino)-1-(1-hydroxycyclohexyl)-1-phenylethanol; (S)-ODV; S-(-)-O-Desmethylvenlafaxine (Note: Common typographical error, correct enantiomer is S-(+)); Major Active Metabolite of Venlafaxine; (S)-O-Desmethylvenlafaxine Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our S-(+)-o-Desmethyl Venlafaxine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity. Avoid prolonged exposure to air and humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.