Description

3-(Trifluoromethoxy)Anisole is a specialized fluorinated aromatic ether building block, recognized by CAS NO 142738-94-1. This compound is valued for its unique trifluoromethoxy (-OCF₃) substituent, which imparts enhanced lipophilicity, metabolic stability, and electronic properties to molecular structures. It is primarily sought by R&D and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated building block for electronic chemicals used in display technologies, leveraging its ability to modify dielectric constant and molecular alignment.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as a precursor for ligands in catalytic systems, benefiting from the electron-withdrawing nature of the -OCF₃ group.
• Material Science Research: Investigated for incorporation into polymers and advanced organic frameworks to tailor thermal stability, solubility, and surface properties.

Basic Information

Product Name	3-(Trifluoromethoxy)Anisole
CAS No.	142738-94-1
Molecular Formula	C₈H₇F₃O₂
Molecular Weight	192.14 g/mol
Synonyms	1-Methoxy-3-(trifluoromethoxy)benzene; 3-(Trifluoromethoxy)phenyl methyl ether; m-(Trifluoromethoxy)anisole; 3-Methoxyphenyl trifluoromethyl ether; Benzene, 1-methoxy-3-(trifluoromethoxy)-; Methyl 3-(trifluoromethoxy)phenyl ether
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.