Description

2,3,5,6-Tetrafluorophenyl Trifluoroacetate is a highly fluorinated organic building block and reagent of significant importance in advanced chemical synthesis. Its value lies in its role as a versatile intermediate for introducing the tetrafluorophenoxy moiety, a key structural feature in the development of pharmaceuticals, agrochemicals, and specialty materials. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable fluorination reagents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring fluorinated aromatic systems to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the tetrafluorophenyl group contributes to product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes, where fluorine atoms improve performance and stability.
• Polymer & Resin Modification: Employed to introduce fluorine into polymer chains, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: Acts as an effective substrate or reagent in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex fluorinated aromatics.
• Protecting Group Chemistry: Can be utilized in synthetic organic chemistry as a protecting group for alcohols or phenols, or as an activating agent for carboxylic acids.

Basic Information

Product Name	2,3,5,6-Tetrafluorophenyl Trifluoroacetate
CAS No.	142685-25-4
Molecular Formula	C8H1F7O2
Molecular Weight	274.08 g/mol
Synonyms	Perfluorophenyl Trifluoroacetate (ambiguous); 2,3,5,6-Tetrafluorophenyl 2,2,2-Trifluoroacetate; Trifluoroacetic Acid 2,3,5,6-Tetrafluorophenyl Ester; Tetrafluorophenyl Trifluoroacetate; TFPTFA; TFP-TFA; 2,3,5,6-Tetrafluorophenyl Ester of Trifluoroacetic Acid
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluorophenyl Trifluoroacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.