Description

Dendrotoxin B is a highly specific and potent neurotoxin isolated from the venom of the Eastern green mamba (*Dendroaspis angusticeps*). This compound is a critical research tool for studying voltage-gated potassium (Kv) channels, particularly the Kv1.1, Kv1.2, and Kv1.6 subtypes. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in fundamental neurological research, ion channel characterization, and the development of novel therapeutic agents targeting neurological disorders.

Application

• Neuroscience Research: A selective probe for blocking specific subtypes of voltage-gated potassium (Kv) channels to study neuronal excitability and signaling.
• Ion Channel Pharmacology: Used in high-throughput screening (HTS) assays to identify and characterize new modulators or blockers of Kv1 channels.
• Toxicology Studies: Serves as a reference standard for understanding the mechanism of action of snake venom components and their physiological effects.
• Drug Discovery: Facilitates the development of novel therapeutics for conditions like epilepsy, autoimmune disorders, and neuropathic pain that involve Kv channel dysfunction.
• Biochemical Assays: Employed in binding studies and structural biology (e.g., X-ray crystallography, cryo-EM) to map channel-toxin interaction sites.
• Academic & Institutional Research: A key reagent for universities and research institutes focusing on cellular electrophysiology and neurobiology.

Basic Information

Product Name	Dendrotoxin B
CAS No.	142661-43-6
Molecular Formula	C184H282N52O53S7
Molecular Weight	~4180 g/mol
Synonyms	DTX-B; Dendrotoxin-B; Dendrotoxin I; Toxin DtX; Dendrotoxin K; Potassium channel toxin α-Dtx; Mamba dendrotoxin
EINECS	Contact for details

Quality Control

Our Dendrotoxin B is produced and handled under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized using advanced analytical techniques, including mass spectrometry (MS) for molecular weight confirmation and HPLC for purity assessment. A comprehensive Certificate of Analysis (COA) detailing purity, potency (via bioassay), and endotoxin levels is provided with every shipment to support your critical research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Biological Activity	Confirmed by Kv1 channel blockade assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.