Description

3-(4-tert-Butylphenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) due to its unique trifluoromethyl ketone moiety. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Precursor: Serves as a starting material for chiral ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for electronic and optical applications.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis projects and scale-up services for clients.

Basic Information

Product Name	3-(4-tert-Butylphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	142505-28-0
Molecular Formula	C₁₃H₁₅F₃O
Molecular Weight	244.25 g/mol
Synonyms	1-[4-(tert-Butyl)phenyl]-3,3,3-trifluoro-1-propanone; 4-tert-Butyl-α,α,α-trifluoroacetophenone; 4-(tert-Butyl)phenyl Trifluoroacetone; p-tert-Butylphenyl Trifluoromethyl Ketone; 3,3,3-Trifluoro-1-(4-tert-butylphenyl)-1-propanone; 1-(4-tert-Butylphenyl)-3,3,3-trifluoropropan-1-one; TFAP-Bu; 142505-28-0
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by GC, HPLC, NMR, and MS to confirm identity and purity. We adhere to strict in-process controls and maintain full traceability. Certificates of Analysis (COA) are available upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.